For me there's no real rule... depending on the guitar and my mood, I use big Ultex 1.14, V-Pick ultra lites (which aren't actually that thin ... .80 mm), and sometimes a Wegen bluegrass pick. I use them until they break, or I notice that it's not playing as accurately as it should, or until I decide a new one sounds better.
But like Bob W., I almost never actually throw one away ... they just kind of circulate around the house like pennies or paper clips or something.
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