I believe Hoffee cases are great, and the quality has improved over the last couple of years. However, I'm not sure I would call the PVC seals waterproof in the sense that they will keep out moisture and control relative humidity. I believe they are water resistant (as in, taking them in the rain won't hurt things), but I don't think you'll be able to go SCUBA diving with your guitar.
They are very big and relatively heavy, though they are making a slimmer version now that is lighter. For most applications, the heavy padding is probably overkill.
I have heard nothing but great things about the recent Caltons, but I believe they are just as heavy, if not heavier.
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