On guitarvideos.com whenever the guys like Stefan Grossman, Fred Sokolow, or Woody Mann down-tune to open D, open G, or dropped D, they simply tune down whatever they already have on the guitar, and I do know that Stefan Grossman uses standard lights - 12-53 D'Aaddarios. If you've just got one guitar and you normally use lights, then I would use those and down-tune when you need to. My feeling is that you're better to be a bit too light with a guitar than too heavy for sheer playability. Even medium lights, 12.5 - 55, in standard can really take it out on your fingers.
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