I'd probably try just leaving it in the original key. But I do move chords all over the neck and if they sound good to me, I use them. If they don't I'll try something else.
With an open C, I make it a C7 and mute the e string. It works fine for me. Little F moves up. D with 4 fingers. E and A, I move around but I still consider them E's and A's. Like I said, if it sounds good I do it, if not I change it.
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