Well, recording from a mic is always better imho. But no, you can certainly install a Fishman USP in a guitar that never had a pickup and not suffer any drawbacks. Just know that the saddle height will have to be adjusted to compensate for the thickness of the pickup.
Having said that the conditions have to be right to install a USP too. IOW if your saddle height is already too low then you might not be able to install one.
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