I use Cubase and have since the start. But if I were starting out I'd use Reaper. It's inexpensive, has all the needed features and then some, and you can lay it out and make it look the way you want.
And if on a budget, the Focusrite stuff is as good as any. But whatever you get, make sure you get at least 2 inputs that have mic preamps so you can record in stereo. You may not think that's important now but you will.
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