I have arthritis at the base of my left hand thumb. I searched and searched for a neck profile that minimized the discomfort I feel playing. The best thing yet is the compound radius neck on the Fender Elite Tele and Strats. I sold a few guitars to pick up one of each. May not work for you, but they are very comfortable for me.
For me, the thinner neck is a plus. The mild V on the Clapton Strats is pretty good too.
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TeleJonz
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