Yep, you have to tweak your chord shapes if you want to play the 6th string.
For example, in one song I do I play a G using 5-5-0-0-3-3. Technically it's a G5 because there's no 3rd in there, but in context it sounds like a G major. E is played 2-2-2-1-0-0; Em becomes 2-2-2-0-0-0. Other chords just omit/mute the 6th string.
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