Scratch the single coil. They are hopeless in many situations. Then, check the lighting. Some LEDs and CFLs will interfere. And make sure you have a high quality cable.
I assume you're plugged into a Hi-Z input with it set appropriately to that mode (if needed - never used one of those mixers). You might also try using a good DI box and go in to a "mic" level input with an XLR cable for better noise control. If the DI box has a ground lift, you can try that, too.
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"I know in the morning that it's gonna be good, when I stick out my elbows and they don't bump wood." - Bill Kirchen
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