I suspect slightly heavier strings would be a good idea. Assuming your setup was a good one and the frets are even, heavier strings will produce a clearer, fuller bottom end at source and also pull the action slightly higher, mitigating the rattle in the process.
Your question about fret buzz and the pickup is a valid one. Assuming again that your pickup is a UST, it senses the sound direct from the string which is where the buzz is most apparent so well worth sorting the buzz out.
A SBT would be slightly more forgiving but not much.
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