I go about this from the bass instead of the melody as a vocal accompaniment style. Then I work out the melody or a guitar solo break section. I also have a handful of solo guitar pieces where I play the melody, the bass line, and everything in between.
I use drop-D a la Mundell Lowe or Johnny Smith in order to get a little more pitch range between the melodies and bass lines.
I’m sort of a “one trick pony” on guitar. I do this one style and that’s it. I seem to impress people at my own gigs, but I wouldn’t be relevant in a band context.
It sounds like this:
https://youtu.be/bnY_-jnjIDo