One of my guitar heroes, Cliff Aungier (RIP), was ambidextrous. He normally played left-handed, but I saw him at jam session once where he picked up a right handed guitar and played it **** near as well as he played left-handed. That's despite being rather drunk at the time....
Here's the man in action, just to give a flavour of his shambolic brilliance (playing Broonzy's Hey Hey his way):
https://youtu.be/yxScfNDQbJA?t=898