I've been following this post to learn something and expect someone with experience will shed some light on what you are considering. My first thought would be since the bridge pin holes won't line up, the bridge pin fit will be degraded. Maybe not enough to matter and possibly if reamed for larger diameter pins it would be ok, but I would like to hear a luthiers opinion.
The second concern is the string path is no longer parallel to the edge of the fret board and might not feel right capering the treble E at the higher frets, possibly pulling a string into the fret bevel (or over the edge). So I think you have answered your own question and the change would not be for the better.
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