I keep it simple. I use an iMac w/Garage Band, Akai EIE Pro 4-Channel Interface. BOSS ME-70 Guitar Effects board, MXL 550 Condensor Vocal Mic, MXL 551r Instrument mic. Pop filter. It has simplified over the years moving from reel-to-reels and rack mounted gear to computer.. I still mic my PA or Crate TX-50 for effect at times when using guitar effects.
New gear to consider - vocal processor.