As a bass player, I will add that the bass player needs be mindful of what the both of you are trying to accomplish as an ensemble. His line makes a very big difference in terms of how "empty" it feels.
In terms of the lead itself, even if flat picking single notes, taking a cross-picking approach and playing lead within the chord forms adds a lot of body and resonance as it allows every note to ring out clearly. Of course, that's easy advice to write on a forum post. Executing it is the real kicker!
