Without knowing the guitar you're playing, the type of bridge it has, the style of playing you do, it is hard to offer much more help than the previous poster.
For me, I use 12-53 on my acoustics and also 12-52 with a wound g on my electrics. But, I do not do string bends. With most pickups on electric guitars, you're going to have to get steel strings for the pickups to work right.
As for difficulty, some bridges make string changes a nightmare. (Wraparound, floyd rose, floating bridge).
Really light gauges like 9 or 8, I find difficult to work with the high e string and not get slippage.
My 2c.
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As my username suggests, huge fan of Yamaha products. Own many acoustic-electric models from 2009-present and a couple electric. Lots of PA too.
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