[drplayer]

Even among the finest Luthiers in the world there is no consensus, so we sure aren't going to solve it here. But for every bolt-on neck builder, there is one like Richard Hoover who believes a dovetail joint is "better". And for every builder using strictly synthetic glues, there is a builder using hide glue (and many more that use it for an upcharge), because they believe in the benefits of it.

Unlike many other things that are left to mere opinion, there have been studies done on the effects on hide glue vs. modern glues, and they were posted here some years ago by an Engineer of some discipline. In brief, the study showed that hide glue DID in fact transfer energy more efficiently, which would just seem to make sense because it's pretty universally known to set harder than modern glues. I believe most would also say that it's better when repairs are needed, because it can be more easily be "melted/softened" (for lack of better terms) and re-set.

So to answer the question of whether hide glue will "...make a difference in the tone/voice", I think the answer is most certainly yes. Now, whether or not that difference is discernible to everyone, or whether or not that difference is viewed as adding to or improving the tone, are entirely different things...things that only each individual can answer for themselves.