I'm assuming we're talking about piezo pickups here. In general, DI boxes that have relatively high input impedances sound better. Upwards of 30 kHz. Also, if it's a passive DI, a big, hefty transformer will sound better than the little fellas you usually find. More thump.
Also, the piezo quack will affect the way you play, or at least it should. On strummy parts, you'll probably want to lay off the treble strings a bit more than you otherwise would.
As for EQ, you'd think there would be a way to zero in on the nasality, but I've never found it. I can make it a different kind of bad -- maybe a bad that works better for a given song -- but it's still lipstick on a pig.
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