I have seen some awesome work on a harp guitar, but what's to say the same thing couldn't of been done on a 6 string. I guess sometimes one can benefit from those added 5 bass notes i just dont think having a whole guitar based on them is really that essential. To each his own i guess.
On the other side of things a nice bassy drone note ringing in the background would give a song that nice full sound hmmmmmmmmm.