I have to agree with Brencat, the worst my HD28 has sounded was when i put a set of medium Elixir PB nanos on it. Bass was tubby and it just didn't have the life in it I was used to. The SP4100's were very bass heavy and the highs a bit too harsh for me. Probably would be a good string for Bluegrass though. Just not my cup of tea.
The best I've tried so far has been the Spectrums, a nice balanced sound with a little bite when pushed, a sweet midrange. Lovin' them so far.
I'll try some DR's on it next.
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John
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