[roylor4]

Originally Posted by buzzardwhiskey

One of the things I've learned is that the "hum/hiss" clean-up plug-in that comes with Reaper doesn't handle tremolo very well. And when I employ the Tube Screamer circuit that comes with the amp, it really hums/hisses something awful.

I'm really thinking quite a lot about replacing the pickups with some humbuckers such as these:

I wouldn't advise switching pickups in a new high-end electric guitar so quickly. You need to learn to get the most out of the equipment the way it is first.

You should evaluate whether the pedals in your effect chain are the best fit for the guitar instead of the other way around IMO.

Also, try changing the order your pedals are lined up first. That's free.