Robert Johnson's Crossroads (according to old blues legends) are at the intersection of US Highway 49 and US Highway 61. 49 goes northward from Gulfport MS and 61 goes from New Orleans to St. Louis, through Memphis.
49 and 61 cross 3 miles south of Clarksdale, MS. Old highway 49 is still there, called "Tallahatchee St." only thing there is an overpass, and a sign that says "watch for children." just down the road is "Shackup Inn". Yeah, dunno.
3 miles to the Delta Blues Museum.
We had family in the Clarksdale area and went through there many times in the '50s and '60s.
Seriously I doubt you'd find a lot of people wanting to be out there at midnight.