There are many examples of lefites playing righty, all the way back to Duane Allman. Being a lefty playing righty I've paid attention to the style of those who are lefty playing righty, and have discovered something: in almost all cases I can recall, the left (dominant) hand performs better than a righty's does and the right hand performs worse than a righty's. Once you get to a certain level playing single-string leads, for instance, it has an effect on style. You'll see a greater reliance on left-hand hammer-ons and pull-offs, for instance, using the greater facility of the left hand to compensate for a less facile right hand. Think of Mark Knopfler.
So, while at some levels it makes little difference at others it can make a world of difference. I had about four lessons when I started before my instructor gave up on me because of my clumsy right hand. Eight years later he served as the promoter when the band I played lead guitar in traveled back to my home town.
Bob
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"It is said, 'Go not to the elves for counsel for they will say both no and yes.' "
Frodo Baggins to Gildor Inglorion, The Fellowship of the Ring
THE MUSICIAN'S ROOM (my website)
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