I believe it will make a definite differance on the saddle. I believe it will make a difference on open strings on the nut. I don't believe bridge pins will make a difference. The strings vibration end points are the saddle and nut (or fret on fretted strings)... I don't believe the bridge pins could possibly have any significant impact on transmission of vibrations into the top. These are just my opinions based upon personal experience.
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